Intestinal immunity in C. elegans is activated by pathogen effector-triggered aggregation of the guard protein TIR-1 on lysosome-related organelles

Y Samantha, KA Wani, ND Peterson, A Page… - Immunity, 2024 - cell.com
Summary Toll/interleukin-1/resistance (TIR)-domain proteins with enzymatic activity are
essential for immunity in plants, animals, and bacteria. However, it is not known how these …

Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity

Y Samantha, R Pukkila-Worley - Cell reports, 2024 - cell.com
Innate immunity in bacteria, plants, and animals requires the specialized subset of
Toll/interleukin-1/resistance gene (TIR) domain proteins that are nicotinamide adenine …

Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches

A Bhatt, BP Mishra, W Gu, M Sorbello, H Xu, T Ve… - IUCrJ, 2024 - journals.iucr.org
The TIR (Toll/interleukin-1 receptor) domain represents a vital structural element shared by
proteins with roles in immunity signalling pathways across phyla (from humans and plants to …

创伤性颈脊髓损伤患者华勒氏变性的磁共振成像研究

袁媛, 周红俊, 卫波, 丛欣莹, 刘根林, 郑樱… - 中国康复理论与 …, 2024 - cjrtponline.com
创伤性颈脊髓损伤患者华勒氏变性的磁共振成像研究 《中国康复理论与实践》 《中国康复理论与
实践》 微信平台 《中国康复理论与实践》 移动平台 《中国康复理论与实践》 中国科技核心期刊(中国 …

Lysosomal integrity suppresses TIR-1/SARM1 aggregation to restrain toxic propagation of p38 innate immunity

SY Tse-Kang, R Pukkila-Worley - bioRxiv, 2024 - biorxiv.org
Innate immunity in bacteria, plants and animals requires the specialized subset of TIR-
domain proteins that are NAD+ hydrolases. Aggregation of these TIR proteins engages their …

Activation of intestinal immunity by pathogen effector-triggered aggregation of lysosomal TIR-1/SARM1

SY Tse-Kang, KA Wani, ND Peterson, A Page… - bioRxiv, 2023 - biorxiv.org
Mechanisms of pathogen recognition in barrier tissues, which interface with both commensal
and virulent bacteria, are critical for health and not fully understood. Here, we discovered a …

Local translation is engaged to sustain synaptic function in impaired Wallerian degeneration

M Paglione, L Restivo, S Zakhia, AL Rosell, M Terenzio… - bioRxiv, 2023 - biorxiv.org
After injury, the severed axon separated from the soma activates programmed axon
degeneration, an evolutionarily conserved pathway to initiate its degeneration within a day …

[PDF][PDF] Local translation is engaged to sustain circuit integrity in severed preserved axonal and synaptic projections

M Paglione, L Restivo, S Zakhia, AL Rosell, M Terenzio… - scholar.archive.org
After injury, the axon separated from the soma activates programmed axon degeneration, an
evolutionarily conserved pathway to initiate its degeneration within a day. However, in …