The axial length of the eye is critical for normal visual function by enabling light to precisely
focus on the retina. The mean axial length of the adult human eye is 23.5 mm, but the …

Monogenic syndromic disorders frequently feature ocular manifestations, one of which is
glaucoma. In many cases, glaucoma in children may go undetected, especially in those that …

Precise regulation of ocular size is a critical determinant of normal visual acuity. Although it
is generally accepted that ocular growth relies on a cascade of signaling events transmitted …

Nanophthalmos is a rare condition defined by a small, structurally normal eye with resultant
high hyperopia. While six genes have been implicated in this hereditary condition (MFRP …

Microphthalmos is a type of developmental disorder ophthalmopathy, which can occur
isolated or combined with other ocular malformations and can occur secondary to a systemic …

Purpose Cataract surgery in patients with nanophthalmos is complicated for
ophthalmologists to perform. Due to the unique ocular anatomy, there is a high incidence of …

Introduction: Long axial length (AL) is a risk factor for myopia. Although family studies
indicate that AL has an important genetic component with heritability estimates up to 0.94 …

Nanophthalmos is characterised by shorter posterior and anterior segments of the eye, with
a predisposition towards high hyperopia and primary angle-closure glaucoma. Variants in …

Background Nanophthalmos (NNO) is a rare condition with significantly shorter axial length
than normal. Several genes are known to cause NNO, among them the MFRP and PRSS56 …

Background/Aims To distinguish the clinical feature of nanophthalmos (NNO) caused by
mutations in protease serine 56 (PRSS56), membrane-type frizzled-related protein (MFRP) …