Fluorescent nucleobases as tools for studying DNA and RNA

W Xu, KM Chan, ET Kool - Nature chemistry, 2017 - nature.com
Understanding the diversity of dynamic structures and functions of DNA and RNA in biology
requires tools that can selectively and intimately probe these biomolecules. Synthetic …

Aptamers from random sequence space: Accomplishments, gaps and future considerations

S Qian, D Chang, S He, Y Li - Analytica Chimica Acta, 2022 - Elsevier
Aptamers are molecular recognition elements made of nucleic acids. Diverse synthetic
aptamers have been discovered in a large number of SELEX experiments since 1990. This …

Metal-mediated DNA base pairing: alternatives to hydrogen-bonded Watson–Crick base pairs

Y Takezawa, M Shionoya - Accounts of Chemical Research, 2012 - ACS Publications
With its capacity to store and transfer the genetic information within a sequence of
monomers, DNA forms its central role in chemical evolution through replication and …

The expanded genetic alphabet

DA Malyshev, FE Romesberg - … Chemie International Edition, 2015 - Wiley Online Library
All biological information, since the last common ancestor of all life on Earth, has been
encoded by a genetic alphabet consisting of only four nucleotides that form two base pairs …

Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation

R Saladino, E Carota, G Botta… - Proceedings of the …, 2015 - National Acad Sciences
Liquid formamide has been irradiated by high-energy proton beams in the presence of
powdered meteorites, and the products of the catalyzed resulting syntheses were analyzed …

[HTML][HTML] Synthetic biology: recent progress, biosafety and biosecurity concerns, and possible solutions

F Wang, W Zhang - Journal of Biosafety and Biosecurity, 2019 - Elsevier
Synthetic biology is a new interdisciplinary research area that uses engineering principles
as guidelines for biological investigation. With research goals to modify existing biological …

The XNA world: progress towards replication and evolution of synthetic genetic polymers

VB Pinheiro, P Holliger - Current opinion in chemical biology, 2012 - Elsevier
Life's diversity is built on the wide range of properties and functions that can be encoded in
natural biopolymers such as polypeptides and nucleic acids. However, despite their …

The expanded central dogma: Genome resynthesis, orthogonal biosystems, synthetic genetics

K Gerecht, N Freund, W Liu, Y Liu… - Annual review of …, 2023 - annualreviews.org
Synthetic biology seeks to probe fundamental aspects of biological form and function by
construction [ie,(re) synthesis] rather than deconstruction (analysis). In this sense, biological …

Preparing synthetic biology for the world

GHG Moe-Behrens, R Davis, KA Haynes - Frontiers in microbiology, 2013 - frontiersin.org
Synthetic Biology promises low-cost, exponentially scalable products and global health
solutions in the form of self-replicating organisms, or “living devices.” As these promises are …

Expansion of the genetic alphabet: A chemist's approach to synthetic biology

AW Feldman, FE Romesberg - Accounts of chemical research, 2018 - ACS Publications
Conspectus The information available to any organism is encoded in a four nucleotide, two
base pair genetic code. Since its earliest days, the field of synthetic biology has endeavored …