The ovarian stroma as a new frontier

HM Kinnear, CE Tomaszewski, AL Chang… - …, 2020 - rep.bioscientifica.com
Historically, research in ovarian biology has focused on folliculogenesis, but recently the
ovarian stroma has become an exciting new frontier for research, holding critical keys to …

A kaleidoscopic view of ovarian genes associated with premature ovarian insufficiency and senescence

Q Yang, S Mumusoglu, Y Qin, Y Sun… - The FASEB …, 2021 - Wiley Online Library
Ovarian infertility and subfertility presenting with premature ovarian insufficiency (POI) and
diminished ovarian reserve are major issues facing the developed world due to the trend of …

Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a …

M Peng, S Tian, Y Song, C Li, Z Ren, M Li - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Eucommia ulmoides Oliv. leaves are the dry
leaves of Eucommia ulmoides Oliv. Modern studies have shown that Eucommia ulmoides …

The stromal microenvironment and ovarian aging: mechanisms and therapeutic opportunities

L Shen, J Liu, A Luo, S Wang - Journal of Ovarian Research, 2023 - Springer
For decades, most studies of ovarian aging have focused on its functional units, known as
follicles, which include oocytes and granulosa cells. However, in the ovarian stroma, there …

Presence of ovarian stromal aberrations after cessation of testosterone therapy in a transgender mouse model

HM Kinnear, PH Hashim, C Dela Cruz… - Biology of …, 2023 - academic.oup.com
Some transmasculine individuals may be interested in pausing gender-affirming
testosterone therapy and carrying a pregnancy. The ovarian impact of taking and pausing …

Androgen excess: a hallmark of polycystic ovary syndrome

K Wang, Y Li, Y Chen - Frontiers in Endocrinology, 2023 - frontiersin.org
Polycystic ovarian syndrome (PCOS) is a metabolic, reproductive, and psychological
disorder affecting 6–20% of reproductive women worldwide. However, there is still no cure …

Expression of genes regulating cell division in porcine follicular granulosa cells

J Kulus, W Kranc, M Kulus, P Dzięgiel, D Bukowska… - Cell Division, 2023 - Springer
Background Cell cycle regulation influences the proliferation of granulosa cells and affects
many processes related to ovarian folliclular growth and ovulation. Abnormal regulation of …

Cellular heterogeneity of the luteinizing hormone receptor and its significance for cyclic GMP signaling in mouse preovulatory follicles

V Baena, CM Owen, TF Uliasz, KM Lowther… - …, 2020 - academic.oup.com
Meiotic arrest and resumption in mammalian oocytes are regulated by 2 opposing signaling
proteins in the cells of the surrounding follicle: the guanylyl cyclase natriuretic peptide …

Induction of Collagen I by CXCL10 in Ovarian Theca–Stroma Cells via the JNK Pathway

C Wang, Y Sun - Frontiers in Endocrinology, 2022 - frontiersin.org
Premature ovarian insufficiency (POI) poses a great threat to reproductive-age women.
Ovarian fibrogenesis is a basic histologic feature of POI. Ovarian theca–stroma cells are …

VCAM1-α4β1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells

K Abe, S Kon, H Kameyama, JD Zhang, K Morohashi… - Scientific reports, 2021 - nature.com
Roles of interstitial tissue in morphogenesis of testicular structures remain less well
understood. To analyze the roles of CD34+ cells in the reconstruction of interstitial tissue …