The founding in 1965 of what is now called the Cambridge Structural Database (CSD) has
reaped dividends in numerous and diverse areas of chemical research. Each of the million …

Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

Charge transfer (CT), occurring from donor to acceptor involving π electrons, plays a
significant role in regulating the emission of materials. Especially, in multicomponent …

In this work, four novel pharmaceutical cocrystals of nitrofurantoin, an antibacterial drug, with
isonicotinamide, picolinamide, 2-hydroxybenzamide, and 2-aminobenzamide have been …

Herein, we reported a new bergenin: 4-aminobenzamide (BGN-4AM) cocrystal with
significantly enhanced solubility and low hygroscopicity probed from two aspects such as …

Solid agrochemicals with poor thermal stability pose a huge challenge to their production
and application. Herein, two low-melting-point fungicides, pyraclostrobin (ZJ) and flusilazole …

This study established a flavonoid cocrystal database, and four machine learning models
[support vector machine (SVM), random forest (RF), logistic regression (LR), and artificial …

Mechanochemistry has been recognized as an optimal route for the synthesis of ionic liquids
incorporating active pharmaceutical ingredients (API-ILs) as it eliminates the need for large …

According to the BCS classification system, the differentiation of drugs is based on two
essential parameters of solubility and permeability, meaning the latter is as pivotal as the …

Thirty-four binary systems of nitrofurantoin with pyridine derivatives were analyzed by
combining virtual (molecular complementarity prediction and hydrogen bond propensity …