The connection between the gut microbiota and the aetiology of obesity and cardiometabolic
disorders is increasingly being recognized by clinicians. Our gut microbiota might affect the …

The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …

Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …

Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy
and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of …

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA
accessibility. Since then, this process has emerged as a controller of histone and nonhistone …

HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often
found together in three major multiprotein co-repressor complexes: Sin3, NuRD …

Obesity and metabolic syndrome are associated with mitochondrial dysfunction and
deranged regulation of metabolic genes. Peroxisome proliferator-activated receptor γ …

Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin
remodeling and have crucial roles in numerous biological processes, largely through their …

Chromatin modifications are sensitive to environmental and nutritional stimuli. Abnormalities
in epigenetic regulation are associated with metabolic disorders such as obesity and …

Histone deacetylase 11 (HDAC11) is the only member of the class IV HDAC, and the latest
member identified. It is highly expressed in brain, heart, kidney and some other organs, and …