Upgrading Treatment and Molecular Diagnosis in Endometrial Cancer—Driving New Tools for Endometrial Preservation?

M Dellino, M Cerbone, AS Laganà, A Vitagliano… - International Journal of …, 2023 - mdpi.com
One emerging problem for onco-gynecologists is the incidence of premenopausal patients
under 40 years of age diagnosed with stage I Endometrial Cancer (EC) who want to …

Oncological outcomes in fertility-sparing treatment in stage IA-G2 endometrial cancer

C Ronsini, L Mosca, I Iavarone, R Nicoletti… - Frontiers in …, 2022 - frontiersin.org
Background The gold standard treatment for early-stage endometrial cancer (EC) is
hysterectomy with bilateral salpingo-oophorectomy (BSO) with lymphadenectomy. In …

The role of adjuvant therapy for the treatment of micrometastases in endometrial cancer: a systematic review and meta-analysis

C Ronsini, S Napolitano, I Iavarone… - Journal of Clinical …, 2024 - mdpi.com
Endometrial cancer is the most incident gynecological cancer. Lymph node dissemination is
one of the most important factors for the patient's prognosis. Pelvic lymph nodes are the …

Fertility Preservation in Endometrial Cancer—Treatment and Molecular Aspects

M Schubert, L Mettler, A Deenadayal Tolani, I Alkatout - Medicina, 2023 - mdpi.com
Endometrial cancer is one of the most common gynecological malignancies worldwide;
incidences are rising, with 417,367 new cases registered in 2020. Of these, the proportion of …

Radiotherapy and chemotherapy features in the treatment for locoregional recurrence of endometrial cancer: A systematic review

C Ronsini, I Iavarone, A Reino, MG Vastarella… - Journal of Personalized …, 2023 - mdpi.com
Radiation therapy (RT) is the standard of care in patients with locoregional or isolated
vaginal recurrence who never underwent irradiation. It is often associated with …

MECOM and the PRDM gene family in uterine endometrial cancer: bioinformatics and experimental insights into pathogenesis and therapeutic potentials

M Lou, L Zou, L Zhang, Y Lu, J Chen, B Zong - Molecular Medicine, 2024 - Springer
To elucidate the expression profiles, methylation states, and clinicopathological significance
of the PRDM gene family, focusing on the MECOM gene's role in uterine endometrial cancer …

The clinicopathological characteristics of POLE-mutated/ultramutated endometrial carcinoma and prognostic value of POLE status: a meta-analysis based on 49 …

Q Wu, N Zhang, X Xie - BMC cancer, 2022 - Springer
Objective This study was designed to investigate the frequency and clinicopathological
characteristics of POLE-mutated/ultramutated (POLEmut) in endometrial carcinoma (EC) …

Endometrial Cancer Individualized Scoring System (ECISS): A machine learning‐based prediction model of endometrial cancer prognosis

SA Shazly, PJ Coronado, E Yılmaz… - … of Gynecology & …, 2023 - Wiley Online Library
Objective To establish a prognostic model for endometrial cancer (EC) that individualizes a
risk and management plan per patient and disease characteristics. Methods A multicenter …

Prognostic impact of pathologic features in molecular subgroups of endometrial carcinoma

M Ruscelli, T Maloberti, AG Corradini, F Rosini… - Journal of Personalized …, 2023 - mdpi.com
The molecular characterization of endometrial carcinoma (EC) has recently been included in
the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated …

Molecular Signature of Endometrial Cancer with Coexistent Adenomyosis: A Multicentric Exploratory Analysis

D Raimondo, A Raffone, A Virgilio, S Ferla, M Maletta… - Cancers, 2023 - mdpi.com
Simple Summary The impact of the molecular signature on the favorable prognosis of
endometrial cancer patients with coexistent adenomyosis is undefined. We aimed to …