Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson's
disease (PD), the second most common neurodegenerative disorder with rapidly rising …

One question in lymphocyte homing is how integrins are rapidly activated to enable
immediate arrest of fast rolling lymphocytes upon encountering chemokines at target …

Chronic Venous Disease (CVD) refers to several pathological and hemodynamic alterations
of the veins of lower limbs causing a wide range of symptoms and signs with a high …

Alterations in vascular extracellular matrix (ECM) components, interactions, and mechanical
properties influence both the formation and stability of atherosclerotic plaques. This review …

The endothelial glycocalyx encompasses the entire endothelial cell, transducing
extracellular signals and regulating vascular permeability and barrier functions. The apical …

Sepsis is a syndrome precipitated by immune dysregulation in response to infection, and
represents a pivotal factor in global mortality attributed to diseases. The recent consensus …

The glycocalyx generally covers almost all cellular surfaces, where it participates in
mediating cell-surface interactions with the extracellular matrix as well as with intracellular …

Physical forces exert profound effects on cells affecting fate, function, and response to
stressors. In the case of the endothelium, the layer that resides in the inner surface of blood …

The brain endothelial cell (BEC) glycocalyx (ecGCx) is a BEC surface coating consisting of a
complex interwoven polysaccharide (sweet husk) mesh-like network of membrane-bound …