Significance: KRIT1 (Krev interaction trapped 1) is a scaffolding protein that plays a critical
role in vascular morphogenesis and homeostasis. Its loss-of-function has been …

Vascular malformations of the brain (VMB) comprise abnormal development of blood
vessels. A small fraction of VMBs causes hemorrhages with neurological morbidity and risk …

Propranolol and atenolol, current therapies for problematic infantile hemangioma (IH), are
composed of R (+) and S (–) enantiomers: the R (+) enantiomer is largely devoid of beta …

Propranolol, a pleiotropic β-adrenergic blocker, has been anecdotally reported to reduce
cerebral cavernous malformations (CCMs) in humans. However, propranolol has not been …

Background Observations in people with cerebral cavernous malformations, and in
preclinical models of this disorder, suggest that the β-blocker propranolol might reduce the …

Cerebral cavernous malformations (CCMs) are vascular malformations in the brain and
spinal cord comprising closely clustered, enlarged capillary channels (caverns) with a single …

Rare Diseases (RD) are defined by their prevalence in less than 5 in 10,000 of the general
population. Considered individually, each RD may seem insignificant, but together they add …

Summary Background Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular
disease, characterized by the presence of multiple vascular malformations that may result in …

Vascular anomalies (VA) are developmental anomalies of veins, arteries, lymphatics or
capillaries thought to be caused by mutations in genes that drive angiogenesis. Treatments …

Background and Purpose: This study aims to assess the influence of modifiable
cardiovascular risk factors on hemorrhage risk of sporadic cerebral cavernous …