Hedgehog (Hh) signaling is a highly conserved pathway that plays a vital role during
embryonic development. Recently, uncontrolled activation of this pathway has been …

The sonic hedgehog (SHH) pathway regulates the development of the central nervous
system in vertebrates. Aberrant regulation of SHH signaling pathways often causes …

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of
the most complex and sophisticated concierges that defend the central nervous system …

Glioblastoma (GBM) is the most fatal and common type of primary malignant tumors in
central nervous system. Chemotherapy drugs are difficult to reach the encephalic region …

Abstract The Sonic Hedgehog (SHH) pathway is crucial regulator of embryonic development
and stemness. Its alteration leads to medulloblastoma (MB), the most common malignant …

Medulloblastoma (MB) is a major pediatric malignant brain tumor that arises in the
cerebellum. MB tumors exhibit highly heterogeneous driven by diverse genetic alterations …

Pediatric brain tumors represent the most common types of childhood cancer and novel
diagnostic and therapeutic solutions are urgently needed. The gold standard treatment …

Prostate cancer (PCa) is the second most frequent cancer in men worldwide. NF-κB seems
to play a key role in cell survival, proliferation and invasion, sustaining the heterogeneous …

Primary malignant brain tumors are the most common solid neoplasm in childhood. Despite
recent advances, many children affected by aggressive or metastatic brain tumors still …

Non-melanoma skin cancers (NMSCs) are the most common human neoplasms world-wide.
In detail, basal cell carcinoma (BCC) is the most frequent malignancy in the fair-skinned …