Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious
public health issue. The current therapeutic options have several disadvantages that make …

Quinones are attractive pharmacological scaffolds for developing new agents for the
treatment of different transmissible and non-transmissible human diseases due to their …

To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this
study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in …

Herein, the design and synthesis of new 2-phenyl (pyridinyl) benzimidazolequinones and
their 5-phenoxy derivatives as potential anti-Trypanosoma cruzi agents are described. The …

African trypanosomes cause diseases in humans and livestock. Human African
trypanosomiasis is caused by Trypanosoma brucei rhodesiense and T. b. gambiense …

In this work, we combined molecular modeling, computational docking and in vitro analysis
to explore the antileishmanial effect of some resveratrol analogs (ResAn), focusing on their …

Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids
Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively, are considered …

Assessment of target druggability guided by search and characterization of hot spots is a
pivotal step in early stages of drug-discovery. The raw output of FTMap provides the data to …

Background and Objectives. Leptadenia hastata is a liana from the family of Asclepiadaceae
used in tropical Africa to treat diabetes mellitus. In this study, we investigated its …