Current and possible future therapeutic options for Huntington's disease

MW Ferguson, CJ Kennedy… - Journal of central …, 2022 - journals.sagepub.com
Huntington's disease (HD) is an autosomal neurodegenerative disease that is characterized
by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). HD …

Huntington disease: a quarter century of progress since the gene discovery

CM Testa, J Jankovic - Journal of the neurological sciences, 2019 - Elsevier
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder
characterized by motor, behavioral, and cognitive manifestations. It is caused by an …

Treatment of tics associated with Tourette syndrome

J Jankovic - Journal of Neural Transmission, 2020 - Springer
Motor and phonic tics associated with Tourette syndrome (TS) can range in severity from
barely perceptible to disabling and most patients have a variety of behavioral co-morbidities …

An update on the pharmacological management of Tourette syndrome and emerging treatment paradigms

A Lenka, J Jankovic - Expert Review of Neurotherapeutics, 2024 - Taylor & Francis
Introduction Tourette syndrome (TS) is a childhood-onset neurobehavioral disorder
characterized by tics. Pharmacotherapy is advised for patients whose symptoms affect their …

Long-term safety and efficacy of deutetrabenazine for the treatment of tardive dyskinesia

HH Fernandez, D Stamler, MD Davis… - Journal of Neurology …, 2019 - jnnp.bmj.com
Objective To evaluate the long-term safety and efficacy of deutetrabenazine in patients with
tardive dyskinesia (TD). Method Patients with TD who completed the 12 week, phase 3 …

Real-world experience with VMAT2 inhibitors

N Niemann, J Jankovic - Clinical neuropharmacology, 2019 - journals.lww.com
Objectives The aim of this study was to review our “real-world” experience with the vesicular
monoamine transporter 2 (VMAT2) inhibitors tetrabenazine (TBZ), deutetrabenazine (DTBZ) …

The pathobiology of depression in Huntington's disease: an unresolved puzzle

KA Jellinger - Journal of Neural Transmission, 2024 - Springer
Huntington's disease (HD) is an autosomal-dominant progressive neurodegenerative
disease that manifests with a triad of symptoms including motor dysfunctions, cognitive …

[HTML][HTML] Comparative analysis of deutetrabenazine and valbenazine as VMAT2 inhibitors for tardive dyskinesia: a systematic review

M Golsorkhi, J Koch, F Pedouim, K Frei… - Tremor and Other …, 2024 - ncbi.nlm.nih.gov
Background: Tardive Dyskinesia (TD) is a neurological disorder characterized by involuntary
movements, often caused by dopamine receptor antagonists. Vesicular Monoamine …

State-of-the-art pharmacological approaches to reduce chorea in Huntington's disease

JS Gibson, DO Claassen - Expert opinion on pharmacotherapy, 2021 - Taylor & Francis
Introduction Chorea is a common motor manifestation of Huntington's disease (HD). Two
vesicular monoamine transporter type 2 (VMAT-2) inhibitors have been approved by the …

Safety and Efficacy of Long‐Term Deutetrabenazine Use in Children and Adolescents with Tics Associated with Tourette Syndrome: An Open‐Label Extension Study

J Jankovic, B Coffey, DO Claassen… - Movement Disorders …, 2023 - Wiley Online Library
Background Tourette syndrome (TS) is a neurodevelopmental disorder characterized by
motor and phonic tics. Objective To assess the safety and efficacy of deutetrabenazine (Teva …