Means, mechanisms and consequences of adenine methylation in DNA
K Boulias, EL Greer - Nature Reviews Genetics, 2022 - nature.com
Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …
Deciphering bacterial epigenomes using modern sequencing technologies
J Beaulaurier, EE Schadt, G Fang - Nature Reviews Genetics, 2019 - nature.com
Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …
Meta-4mCpred: a sequence-based meta-predictor for accurate DNA 4mC site prediction using effective feature representation
DNA N4-methylcytosine (4mC) is an important genetic modification and plays crucial roles in
differentiation between self and non-self DNA and in controlling DNA replication, cell cycle …
differentiation between self and non-self DNA and in controlling DNA replication, cell cycle …
Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA
Bisulfite sequencing (BS-seq) to detect 5-methylcytosine (5mC) is limited by lengthy reaction
times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U conversion …
times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U conversion …
iDNA4mC: identifying DNA N4-methylcytosine sites based on nucleotide chemical properties
Abstract Motivation DNA N4-methylcytosine (4mC) is an epigenetic modification. The
knowledge about the distribution of 4mC is helpful for understanding its biological functions …
knowledge about the distribution of 4mC is helpful for understanding its biological functions …
Nucleic acid modifications in regulation of gene expression
Nucleic acids carry a wide range of different chemical modifications. In contrast to previous
views that these modifications are static and only play fine-tuning functions, recent research …
views that these modifications are static and only play fine-tuning functions, recent research …
Exploring sequence-based features for the improved prediction of DNA N4-methylcytosine sites in multiple species
Motivation As one of important epigenetic modifications, DNA N4-methylcytosine (4mC) is
recently shown to play crucial roles in restriction–modification systems. For better …
recently shown to play crucial roles in restriction–modification systems. For better …
DeepTorrent: a deep learning-based approach for predicting DNA N4-methylcytosine sites
Q Liu, J Chen, Y Wang, S Li, C Jia… - Briefings in …, 2021 - academic.oup.com
Abstract DNA N4-methylcytosine (4mC) is an important epigenetic modification that plays a
vital role in regulating DNA replication and expression. However, it is challenging to detect …
vital role in regulating DNA replication and expression. However, it is challenging to detect …
Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA
ZK O'Brown, K Boulias, J Wang, SY Wang… - BMC genomics, 2019 - Springer
Background Directed DNA methylation on N6-adenine (6mA), N4-cytosine (4mC), and C5-
cytosine (5mC) can potentially increase DNA coding capacity and regulate a variety of …
cytosine (5mC) can potentially increase DNA coding capacity and regulate a variety of …
Navigating the pitfalls of mapping DNA and RNA modifications
Y Kong, EA Mead, G Fang - Nature Reviews Genetics, 2023 - nature.com
Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …
important regulatory information. Reliable high-resolution mapping of these modifications is …