The posterior segments of the eye are exquisitely protected from the external environment.
This poses unique and fairly challenging hurdles for drug delivery. It is somewhat dogmatic …

Diabetic retinopathy is associated with hyperglycemia, and there is convincing evidence that
oxidative stress (the overproduction of reactive oxygen species (ROS)) measured indirectly …

OBJECTIVE—This study determined the effects of high glucose exposure and cytokine
treatment on generation of reactive oxygen species (ROS) and activation of inflammatory …

Endothelial metabolism is a promising target for vascular functional regulation and disease
therapy. Glucose is the primary fuel for endothelial metabolism, supporting ATP generation …

To study the relationship between the aldose reductase gene and diabetic complications, an
(AC) n dinucleotide repeat sequence 2.1 kb upstream of the transcription start site of this …

Diabetic retinopathy (DR) is the most common reason for blindness in working-age
individuals globally. Prolonged high blood glucose is a main causative factor for DR …

This study aimed at verifying whether thiamine, a co-enzyme which decreases intracellular
glycolysis metabolites by allowing pyruvate and glyceraldheyde 3-phosphate to enter the …

In this review, we present a discussion of diabetes and its complications, including the
macrovascular and microvascular effects, with the latter of consequence to the retina. We …

We investigated the hypothesis that benfotiamine, a lipophilic derivative of thiamine, affects
replication delay and generation of advanced glycosylation endproducts (AGE) in human …

Introduction: The impact of vision debilitating diseases is a global public health concern,
which will continue until effective preventative and management protocols are developed …