G protein-coupled receptors (GPCRs) are the largest group of cell surface receptors in
humans that signal in response to diverse inputs and regulate a plethora of cellular …

Given the global burden of heart failure, strategies to understand the underlying cause or to
provide prognostic information are critical to reducing the morbidity and mortality associated …

Natural genetic variation in the human genome is a cause of individual differences in
responses to medications and is an underappreciated burden on public health. Although …

Heart failure (HF), the leading cause of death in the western world, develops when a cardiac
injury or insult impairs the ability of the heart to pump blood and maintain tissue perfusion. It …

The seventeenth edition of Harrison s has a full-color format that draws from and extends the
excellent appearance of the sixteenth edition to make the content more accessible and …

Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers
countermeasures aimed to restore cardiac output. These responses are compensatory at …

Over the past decade, pharmacogenetic testing has emerged in clinical practice to guide
selected cardiovascular therapies. The most common implementation in practice is …

Aims Despite major improvements in pharmacological and device treatments, heart failure
remains a syndrome with high morbidity and mortality, poor quality of life, and high health …

Genomics of Cardiovascular Disease | New England Journal of Medicine Skip to main content
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Heart failure, or congestive heart failure, is a condition in which the heart cannot supply the
body's tissues with enough blood. The result is a cascade of changes that lead to severe …