NMR spectroscopy for metabolomics research
Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …
three principal analytical techniques used in metabolomics (the other two being gas …
Dynamic nuclear polarization for sensitivity enhancement in biomolecular solid-state NMR
T Biedenbänder, V Aladin, S Saeidpour… - Chemical …, 2022 - ACS Publications
Solid-state NMR with magic-angle spinning (MAS) is an important method in structural
biology. While NMR can provide invaluable information about local geometry on an atomic …
biology. While NMR can provide invaluable information about local geometry on an atomic …
Advances in nano-and microscale NMR spectroscopy using diamond quantum sensors
Quantum technologies have seen a rapid developmental surge over the last couple of years.
Though often overshadowed by quantum computation, quantum sensors show tremendous …
Though often overshadowed by quantum computation, quantum sensors show tremendous …
Temperature Cycling Enables Efficient 13C SABRE-SHEATH Hyperpolarization and Imaging of [1-13C]-Pyruvate
Molecular metabolic imaging in humans is dominated by positron emission tomography
(PET). An emerging nonionizing alternative is hyperpolarized MRI of 13C-pyruvate, which is …
(PET). An emerging nonionizing alternative is hyperpolarized MRI of 13C-pyruvate, which is …
Hyperpolarized water as universal sensitivity booster in biomolecular NMR
NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …
high (atomistic) resolution in their native solution state. However, this method's low …
Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution
Hyperpolarized fumarate is a promising biosensor for carbon-13 magnetic resonance
metabolic imaging. Such molecular imaging applications require nuclear hyperpolarization …
metabolic imaging. Such molecular imaging applications require nuclear hyperpolarization …
NMR as a “gold standard” method in drug design and discovery
Studying disease models at the molecular level is vital for drug development in order to
improve treatment and prevent a wide range of human pathologies. Microbial infections are …
improve treatment and prevent a wide range of human pathologies. Microbial infections are …
Recent advances in the application of parahydrogen in catalysis and biochemistry
G Buntkowsky, F Theiss, J Lins, YA Miloslavina… - RSC …, 2022 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI)
are analytical and diagnostic tools that are essential for a very broad field of applications …
are analytical and diagnostic tools that are essential for a very broad field of applications …
SABRE: Chemical kinetics and spin dynamics of the formation of hyperpolarization
In this review, we present the physical principles of the SABRE (Signal Amplification By
Reversible Exchange) method. SABRE is a promising hyperpolarization technique that …
Reversible Exchange) method. SABRE is a promising hyperpolarization technique that …
Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1–13C] pyruvate in vivo
K MacCulloch, A Browning, DOG Bedoya… - Journal of magnetic …, 2023 - Elsevier
Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as
Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to …
Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to …