Surface modification and endothelialization of vascular biomaterials are common
approaches that are used to both resist the nonspecific adhesion of proteins and improve …

Blood contact with biomaterials triggers activation of multiple reactive mechanisms that can
impair the performance of implantable medical devices and potentially cause serious …

The adsorption of proteins is the initiating event in the processes occurring when blood
contacts a “foreign” surface in a medical device, leading inevitably to thrombus formation …

The characteristic molecular composition of the different glycosaminoglycans (GAGs) is
related to their role as structural components and regulators of a multitude of functions of …

Device-associated clot formation and poor tissue integration are ongoing problems with
permanent and temporary implantable medical devices. These complications lead to …

Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for
the short-and long-term applications of medical devices such as cardiovascular stents …

Host responses toward foreign implants that lead to chronic inflammation and fibrosis may
result in failure of the biomedical device. To solve these problems, first a better …

The development of blood-compatible materials represents a grand challenge in
biomaterials science. Blood is a complex fluid containing many types of living cells …

The use of biomaterials in implanted medical devices remains hampered by platelet
adhesion and blood coagulation. Thrombus formation is a prevalent cause of failure of these …

Thrombosis associated with medical devices may lead to dramatic increases in morbidity,
mortality and increased health care costs. Innovative strategies are being developed to …