Anticancer therapeutic potential of benzofuran scaffolds
Benzofuran moiety is the main component of many biologically active natural and synthetic
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
Hydrazinecarboxamides: comprehensive review of their anticancer, anticonvulsive, anti-inflammatory, enzyme inhibition, antioxidant and other activities
M Krátký, NH Houngbedji, J Vinšová - European Journal of Medicinal …, 2024 - Elsevier
This review comprehensively summarizes recent advances in the field of
hydrazinecarboxamide (semicarbazide) derivatives, highlighting their significant therapeutic …
hydrazinecarboxamide (semicarbazide) derivatives, highlighting their significant therapeutic …
Discovery of new nicotinamides as apoptotic VEGFR-2 inhibitors: Virtual screening, synthesis, anti-proliferative, immunomodulatory, ADMET, toxicity, and molecular …
RG Yousef, A Ibrahim, MM Khalifa… - Journal of enzyme …, 2022 - Taylor & Francis
A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual
screening was conducted for the hypothetical library using in silico docking, ADMET, and …
screening was conducted for the hypothetical library using in silico docking, ADMET, and …
Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
Abstract New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
Discovery of new VEGFR-2 inhibitors: design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies
EB Elkaeed, RG Yousef, MM Khalifa, A Ibrahim… - Molecules, 2022 - mdpi.com
Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
Microbial Multidrug Resistance (MDR) is an emerging global crisis. Derivatization of natural
or synthetic scaffolds is among the most reliable strategies to search for and obtain novel …
or synthetic scaffolds is among the most reliable strategies to search for and obtain novel …
Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M
AA Gaber, M Sobhy, A Turky… - Journal of Enzyme …, 2022 - Taylor & Francis
Abstract New 1 H-pyrazolo [3, 4-d] pyrimidine derivatives were designed and synthesised to
act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives …
act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives …
1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies
In the current work, some 1, 3, 4-oxadiazole-naphthalene hybrids were designed and
synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for …
synthesised as VEGFR-2 inhibitors. The synthesised compounds were evaluated in vitro for …
Design, synthesis, and anti-cancer evaluation of new pyrido [2, 3-d] pyrimidin-4 (3H)-one derivatives as potential EGFRWT and EGFRT790M inhibitors and apoptosis …
HSA Elzahabi, ES Nossier, RA Alasfoury… - Journal of Enzyme …, 2022 - Taylor & Francis
A new series of pyrido [2, 3-d] pyrimidin-4 (3H)-one derivatives having the essential
pharmacophoric features of EGFR inhibitors has been designed and synthesised. Cell …
pharmacophoric features of EGFR inhibitors has been designed and synthesised. Cell …
Phthalazone tethered 1, 2, 3-triazole conjugates: In silico molecular docking studies, synthesis, in vitro antiproliferative, and kinase inhibitory activities
Abstract New phthalazone tethered 1, 2, 3-triazole derivatives 12–21 were synthesized
utilizing the Cu (I)-catalyzed click reactions of alkyne-functionalized phthalazone 1 with …
utilizing the Cu (I)-catalyzed click reactions of alkyne-functionalized phthalazone 1 with …