The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …

Many diseases are caused by insufficient expression of mutated genes and would benefit
from increased expression of the corresponding protein. However, in drug development, it …

Introduction lncRNAs are major players in regulatory networks orchestrating multiple cellular
functions, such as 3D chromosomal interactions, epigenetic modifications, gene expression …

Foundational models of transcriptional regulation involve the assembly of protein complexes
at DNA elements associated with specific genes. These assemblies, which can include …

B cell development is linked to successful V (D) J recombination, allowing B cell receptor
expression and ultimately antibody secretion for adaptive immunity. Germline noncoding …

The recent discovery of vast non-coding RNA-based regulatory networks that can be easily
modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities …

Despite an ever-increasing appreciation of how protein-coding genes shape immune
responses, the molecular underpinnings of immune regulation remain incompletely …

RNA molecules tend to form intricate tertiary structures via intramolecular RNA–RNA
interactions (RRIs) to regulate transcription, RNA processing, and translation processes. In …

Chemical modifications of nucleotides expand the complexity and functional properties of
genomes and transcriptomes. A handful of modifications in DNA bases are part of the …

Genome sequencing in the clinic often allows patients to receive a molecular diagnosis.
However, variants are most often evaluated for pathogenicity, neglecting potential treatability …