Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …

Helminth parasite infections are associated with a battery of immunomodulatory
mechanisms that affect all facets of the host immune response to ensure their persistence …

The prospect of transplanting cells and tissues without the risk of immune rejection or the
need for powerful immunosuppressive drugs is the 'holy grail'of transplantation medicine …

Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …

Epidemiological and interventional human studies, as well as experiments in animal
models, strongly indicate that helminth parasitic infections can confer protection from …

There is increasing interest in helminth parasite modulation of the immune system, both from
the fundamental perspective of the “arms race” between host and parasite, and equally …

Extracellular vesicles (EVs) released by parasites have important roles in establishing and
maintaining infection. Analysis of the soluble and vesicular secretions of adult Fasciola …

Major advances have been made in identifying potential vaccine molecules for the control of
fasciolosis in livestock but we have yet to reach the level of efficacy required for …

During endosome maturation, neutral sphingomyelinase 2 (nSMase2, encoded by SMPD3)
is involved in budding of intraluminal vesicles (ILVs) into late endosomes or multivesicular …

The liver fluke, Fasciola hepatica, causes fascioliasis in domestic animals (sheep, cattle), a
global disease that is also an important infection of humans. As soon as the parasite invades …