[HTML][HTML] Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia
X Li, W Li, Y Zhang, L Xu, Y Song - Genes & Diseases, 2024 - Elsevier
The advent of tyrosine kinase inhibitors (TKI) targeting BCR-ABL has drastically changed the
treatment approach of chronic myeloid leukemia (CML), greatly prolonged the life of CML …
treatment approach of chronic myeloid leukemia (CML), greatly prolonged the life of CML …
Emerging roles of the HECT-type E3 ubiquitin ligases in hematological malignancies
VS Delvecchio, C Fierro, S Giovannini, G Melino… - Discover Oncology, 2021 - Springer
Ubiquitination-mediated proteolysis or regulation of proteins, ultimately executed by E3
ubiquitin ligases, control a wide array of cellular processes, including transcription, cell …
ubiquitin ligases, control a wide array of cellular processes, including transcription, cell …
The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia
X Lu, X Huang, H Xu, S Lu, S You, J Xu, Q Zhan… - Cell Death …, 2022 - nature.com
Acute lymphoblastic leukemia (ALL) has been a huge threat for people's health and finding
effective target therapy is urgent and important. WWP2, as one of E3 ubiquitin ligase, is …
effective target therapy is urgent and important. WWP2, as one of E3 ubiquitin ligase, is …
[HTML][HTML] UBE2L3 promotes benzene-induced hematotoxicity via autophagy-dependent ferroptosis
B Wang, F Li, J Hu, F Sun, L Han, J Zhang… - … and Environmental Safety, 2024 - Elsevier
Benzene is a common environmental pollutant and significant health hazard. Low-dose
benzene exposure is common in most industrial settings, and some workers exhibit …
benzene exposure is common in most industrial settings, and some workers exhibit …
Modulation of plasma proteomic profile by regular training in male and female basketball players: a preliminary study
Monitoring fatigue and recovery during training periods contributes to identifying the best
training methods to achieve sports performance. To date, little is known about sex-related …
training methods to achieve sports performance. To date, little is known about sex-related …
The Downregulation of Both Giant HERCs, HERC1 and HERC2, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with …
MS Ali, S Magnati, C Panuzzo, D Cilloni… - Journal of clinical …, 2022 - mdpi.com
Large HERC E3 ubiquitin ligase family members, HERC1 and HERC2, are staggeringly
complex proteins that can intervene in a wide range of biological processes, such as cell …
complex proteins that can intervene in a wide range of biological processes, such as cell …
Identification of ubiquitination-related hub genes in chronic myeloid leukemia cell by bioinformatics analysis
Q Zhou, Z Li, L Meng, Y Wang, MS Ashaq, Y Li… - Journal of …, 2024 - jcancer.org
Purpose: Chronic myeloid leukemia stem cells (CML-LSCs) are posited as the primary
instigators of resistance to tyrosine kinase inhibitors (TKIs) and recurrence of CML …
instigators of resistance to tyrosine kinase inhibitors (TKIs) and recurrence of CML …
[HTML][HTML] E3 泛素连接酶WWP2 通过蛋白酶体途径调控p21 的稳定性
董超， 张丽君 - 中国医科大学学报, 2022 - html.rhhz.net
目的探讨含WW 结构域的E3 泛素蛋白连接酶2 (WWP2) 调控p21 稳定性的潜在作用机制.
方法通过免疫共沉淀及Western blotting 检测HEK 293T 细胞中WWP2 与p21 的结合情况 …
方法通过免疫共沉淀及Western blotting 检测HEK 293T 细胞中WWP2 与p21 的结合情况 …