Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

Upon entering the biological milieu, nanomedicines swiftly interact with the surrounding
tissue fluid, subsequently being enveloped by a dynamic interplay of biomacromolecules …

Checkpoint blockade immunotherapy (CBI) have exhibited remarkable benefits for cancer
therapy. However, the low responsivity of CBI hinders its application in treatment of bladder …

Nanoparticles for the detection and treatment of cancer have suffered from limited clinical
translation. A key problem has been the lack of understanding of the mechanisms of …

Nanomedicines are extensively explored for cancer therapy. By delivering drug molecules
more efficiently to pathological sites and by attenuating their accumulation in healthy organs …

The tumor microenvironment (TME), which is mostly composed of tumor cells, immune cells,
signaling molecules, stromal tissue, and the vascular system, is an integrated system that is …

Immunotherapy is a promising strategy to inhibit the progression of solid tumors. However,
current vaccine adjuvants represented by aluminum adjuvant (Alum) fail to adjuvant tumor …

Cancer immunotherapy has emerged as a promising approach to cancer treatment in recent
years. The physical and chemical properties of nanocarriers are critical factors that regulate …

Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Injectable biomaterials, including bulk materials and particulate materials, can be delivered
in a minimally invasive way and may provide alternative treatment options for conditions that …