Bacterial-induced or passively administered interferon gamma conditions the lung for early control of SARS-CoV-2

KL Hilligan, S Namasivayam, CS Clancy… - Nature …, 2023 - nature.com
Abstract Type-1 and type-3 interferons (IFNs) are important for control of viral replication;
however, less is known about the role of Type-2 IFN (IFNγ) in anti-viral immunity. We …

Tuberculosis and COVID-19 in the elderly: factors driving a higher burden of disease

A Allué-Guardia, JB Torrelles, A Sigal - Frontiers in Immunology, 2023 - frontiersin.org
Mycobacterium tuberculosis (M. tb) and SARS-CoV-2 are both infections that can lead to
severe disease in the lower lung. However, these two infections are caused by very different …

BCG mediated protection of the lung against experimental SARS-CoV-2 infection

KL Hilligan, S Namasivayam, A Sher - Frontiers in Immunology, 2023 - frontiersin.org
The observation of reduced COVID-19 incidence and severity in populations receiving
neonatal intradermal BCG vaccination vaccine raised the question of whether BCG can …

Protective interplay: Mycobacterium tuberculosis diminishes SARS-CoV-2 severity through innate immune priming

BD Williams, D Ferede, HFM Abdelaal… - Frontiers in …, 2024 - frontiersin.org
At the beginning of the COVID-19 pandemic those with underlying chronic lung conditions,
including tuberculosis (TB), were hypothesized to be at higher risk of severe COVID-19 …

T Cell Response in Tuberculosis-Infected Patients Vaccinated against COVID-19

LHA Cavalcante-Silva, EG Leite, FS Almeida… - Microorganisms, 2023 - mdpi.com
Many studies have focused on SARS-CoV-2 and Mycobacterium tuberculosis (Mtb) co-
infection consequences. However, after a vaccination plan against COVID-19, the cases of …

[HTML][HTML] The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication

PJ Baker, AC Bohrer, E Castro, EP Amaral… - bioRxiv, 2024 - ncbi.nlm.nih.gov
SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from
asymptomatic infection to fatal disease. Co-morbidities, sex, age, host genetics and vaccine …

Gamma Delta T cell Responses to Diverse Diseases: Tuberculosis, Cancer and COVID-19

A Morrison - 2024 - oro.open.ac.uk
γδ T cells are unconventional cells involved in innate and adaptive immunity. They are able
to respond rapidly and have roles in a range of diseases. The tuberculosis (TB) vaccine …

[图书][B] Disrupting the Balance: On the Host-Pathogen Homeostasis of M. tuberculosis From Vaccine Characterization to Superinfection Dynamics

RE Hildebrand - 2023 - search.proquest.com
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects a quarter of the
world population resulting in an average of 1.5 million deaths annually. Mycobacterium …