Major progress has been recently made in understanding the molecular pathogenesis of
myeloproliferative neoplasms (MPN). Mutations in one of four genes—JAK2, MPL, CALR …

Signal Transducer and Activator of Transcription (STAT) 3 and 5 are important effectors of
cellular transformation, and aberrant STAT3 and STAT5 signaling have been demonstrated …

Myeloproliferative neoplasms (MPNs) are hematological diseases that are driven by somatic
mutations in hematopoietic stem and progenitor cells. These mutations include JAK2, CALR …

Megakaryocytes play a key role in the JAK2, MPL, and CALR mutated MPNs by promoting
myeloproliferation and fibrosis. Recent studies have shown that the aberrant expansion in …

Hematopoietic stem and progenitor cells (HSPCs) maintain blood-forming and immune
activity, yet intrinsic regulators of HSPCs remain elusive. STAT3 function in HSPCs has been …

Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by cytopenia and
extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological …

Myeloproliferative neoplasms (MPNs) are a class of hematologic diseases characterized by
aberrant proliferation of one or more myeloid lineages and progressive bone marrow …

Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central
orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between …

The JAK/STAT pathway is constitutively activated in myeloproliferative neoplasms and can
be inhibited by ruxolitinib, a selective JAK1/2 inhibitor. The JAK2 V617F mutation leads to …

The regulation of hematopoietic stem cell (HSC) emergence during development provides
important information about the basic mechanisms of blood stem cell generation, expansion …