Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

The cornea and the skin are both organs that provide the outer barrier of the body. Both
tissues have developed intrinsic mechanisms that protect the organism from a wide range of …

The presence of γδ T cell receptor (TCR)–expressing cells in the epidermis of mice, termed
dendritic epidermal T cells (DETCs), is well established. Because of their strict epidermal …

Membrane nanotubes are a recently discovered form of cellular protrusion between two or
more cells whose functions include cell communication, environmental sampling, and …

Balanced immune responses in the eyes are crucial to preserve vision. The ocular immune
system has long been considered distinct, owing to the so-called 'immune privilege'of its …

The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …

Plasmacytoid dendritic cells (pDCs) are a unique subpopulation of immune cells, distinct
from classical dendritic cells. pDCs are generated in the bone marrow and following …

The mouse dura mater, pia mater, and choroid plexus contain resident macrophages and
dendritic cells (DCs). These cells participate in immune surveillance, phagocytosis of …

Pseudomonas aeruginosa is a major cause of blindness and visual impairment in the United
States and worldwide. Using a murine model of keratitis in which abraded corneas are …