Targeting sleep physiology to modulate glymphatic brain clearance

T van Hattem, L Verkaar, E Krugliakova… - …, 2024 - journals.physiology.org
Sleep has been postulated to play an important role in the removal of potentially neurotoxic
molecules, such as amyloid-β, from the brain via the glymphatic system. Disturbed sleep, on …

Current and Emerging Sleep Interventions for Older Adults with or without Mild Cognitive Impairment

A Suraev, SD Kong, Z Menczel Schrire, BA Tran… - … Treatment Options in …, 2024 - Springer
Abstract Purpose of Review This systematic scoping review examines evidence from the last
five years on sleep interventions in cognitive healthy older adults and those with mild …

[HTML][HTML] mCLAS adaptively rescues disease-specific sleep and wake phenotypes in neurodegeneration

I Dias, CR Baumann, D Noain - Sleep Medicine, 2024 - Elsevier
Sleep alterations are hallmarks of prodromal Alzheimer's (AD) and Parkinson's disease
(PD), with fundamental neuropathological processes of both diseases showing susceptibility …

Pharmacological enhancement of slow-wave activity at an early disease stage improves cognition and reduces amyloid pathology in a mouse model of Alzheimer's …

S Kollarik, D Bimbiryte, A Sethi, I Dias… - Frontiers in Aging …, 2025 - frontiersin.org
Introduction Improving sleep in murine Alzheimer's disease (AD) is associated with reduced
brain amyloidosis. However, the window of opportunity for successful sleep-targeted …

Multi-night acoustic stimulation is associated with better sleep, amyloid dynamics, and memory in older adults with cognitive impairment

CJ Zeller, M Wunderlin, K Wicki, CE Teunissen… - GeroScience, 2024 - Springer
Sleep is a potential early, modifiable risk factor for cognitive decline and dementia. Impaired
slow wave sleep (SWS) is pronounced in individuals with cognitive impairment (CI) …

Emerging Technologies to Track and Improve Sleep Health

KH Ji, CH Yun - Sleep Medicine Clinics, 2024 - sleep.theclinics.com
With the introduction of new technologies designed to track and improve sleep quality, sleep
and brain health have gained significant attention. Sleep is a vital process for maintaining …

Acoustic stimulation during slow wave sleep shows delayed effects on memory performance in older adults

M Wunderlin, CJ Zeller, K Wicki, C Nissen… - Frontiers in …, 2024 - frontiersin.org
Introduction In young healthy adults, phase-locked acoustic stimulation (PLAS) during slow
wave sleep (SWS) can boost over-night episodic memory consolidation. In older adults …

Rapid eye movement sleep, the Swiss army knife in neurodegenerative disease?

CR Baumann, SJ Schreiner - Sleep, 2024 - academic.oup.com
In recent years, the interest in the multiple interactions between sleep and
neurodegenerative disease, particularly Alzheimer and Parkinson disease, grew …

Can Auditory Stimulation Improve Sleep Apnea? Preliminary results of explorative measurements

DD Kranz, M Salanitro, E Osmers… - Current Directions in …, 2024 - degruyter.com
Recent advancements in the field of acoustic stimulation have shown promising effects on
the autonomic nervous system, influencing parameters such as heart rate [1] and cognitive …

Closed-loop auditory stimulation of slow-wave sleep: applications and mechanisms of function

D Urbaczka Dudysová - 2024 - dspace.cuni.cz
Non-pharmacological manipulations of sleep represent an important tool to study the
function of sleep causally. Auditory stimulation, and closed-loop auditory stimulation (CLAS) …