CDC45-MCM2-7-GINS (CMG) helicase assembly is the central event in eukaryotic
replication initiation. In yeast, a multi-subunit “pre-loading complex”(pre-LC) accompanies …

Accurate and complete replication of genetic information is a fundamental process of every
cell division. The replication licensing is the first essential step that lays the foundation for …

Accurate and integral cellular DNA replication is modulated by multiple replication‐
associated proteins, which is fundamental to preserve genome stability. Furthermore …

Acute protein knockdown is a powerful approach to dissecting protein function in dynamic
cellular processes. We previously reported an improved auxin-inducible degron system …

The mini-chromosome maintenance proteins 2–7 (MCM2–7) hexamer is a protein complex
that is key for eukaryotic DNA replication, which occurs only once per cell cycle. To achieve …

Simple Summary The intestinal epithelium is one of the tissues that renews the fastest in the
body. This process is driven by intestinal stem cells and is greatly influenced by adenosine …

CMG (Cdc45-MCM2-7-GINS) helicase assembly is the central event in eukaryotic replication
initiation. In yeast, a multi-subunit “pre-Loading Complex”(pre-LC) accompanies GINS to …

Background Minichromosome maintenance complex component 3 (MCM3) plays a key role
in various tumours. However, it remains largely unknown what the specific role and clinical …

Single nucleotide polymorphisms (SNPs) are one of the most common determinants and
potential biomarkers of human disease pathogenesis. SNPs could alter amino acid …

Background Aberrant DNA replication is the main source of genomic instability that leads to
tumorigenesis and progression. MCM2, a core subunit of eukaryotic helicase, plays a vital …