Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

Acetylation of histones is an essential element regulating chromatin structure and
transcription. MYST (Moz, Ybf2/Sas3, Sas2, Tip60) proteins form the largest family of histone …

Both transcription and post-transcriptional processes, such as alternative splicing, play
crucial roles in controlling developmental programs in metazoans. Recently emerged RNA …

The severity of Alzheimer9s disease (AD) progression involves a complex interplay of
genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT) …

Regulation of secondary metabolite (SM) gene clusters in A spergillus nidulans has been
shown to occur through cluster‐specific transcription factors or through global regulators of …

Abstract Tat‐interactive protein 60 (Tip60) is a member of the MYST family, proteins of which
are related by an atypical histone acetyltransferase (HAT) domain. Although Tip60 has been …

The chromodomain motif is found among certain chromosomal proteins of all eukaryotes.
The chromodomain fold–three beta strands packed against a C-terminal alpha helix …

Transcriptional coregulators, including the acetyltransferase Tip60, have a key role in
complex cellular processes such as differentiation. Whereas post-translational modifications …

Disruption of epigenetic gene control mechanisms in the brain causes significant cognitive
impairment that is a debilitating hallmark of most neurodegenerative disorders, including …

Axonal transport defects and axonopathy are prominent in early preclinical stages of
Alzheimer's disease (AD), often preceding known disease-related pathology by over a year …