The type VI secretion system (T6SS) is a macromolecular machine that delivers protein
effectors into both prokaryotic and eukaryotic cells, therefore participating in interbacterial …

Francisella tularensis is the causative agent of the acute disease tularemia. Due to its
extreme infectivity and ability to cause disease upon inhalation, F. tularensis has been …

Bacteria with two cell membranes (diderms) have evolved complex systems for protein
secretion. These systems were extensively studied in some model bacteria, but the …

We report a high-throughput platform for delivering large cargo elements into 100,000 cells
in 1 min. Our biophotonic laser-assisted surgery tool (BLAST) generates an array of …

Type VI secretion systems (T6SS) have been studied primarily in the context of pathogenic
bacteria-host interactions. Recent data suggest, however, that these versatile secretion …

Intracellular bacterial pathogens cause a wide range of diseases and significantly contribute
to the morbidity and mortality associated with infectious diseases worldwide (1‐16)(Table 1) …

Inflammasome activation is an innate host defense mechanism initiated upon sensing
pathogens or danger in the cytosol. Both autophagy and cell death are cell autonomous …

Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …

Type VI secretion systems (T6SSs) are newly identified contractile nanomachines that
translocate effector proteins across bacterial membranes. The Francisella pathogenicity …

Inflammasomes are multi‐protein signaling platforms that upon activation trigger the
maturation of the pro‐inflammatory cytokines, interleukin‐1β (IL‐1β) and IL‐18, and cell …