FMS-like tyrosine kinase 3 (FLT3) mutations occur in almost 30% of acute myeloid leukemia
(AML) patients. Despite the initial clinical efficacy of FLT3 inhibitors, many treated AML …

Our research laboratory has a longstanding interest in developmental disorders and
embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver …

In this study, new 7-chloro-4-aminoquinoline-benzimidazole compounds were synthesized
and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the …

The autophagy process appears as a promising target for anticancer interventions.
Chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) are the only FDA-approved …

Newly synthesized 7-chloro-4-aminoquinoline–benzimidazole hybrids were characterized
by NMR and elemental analysis. Compounds were tested for their effects on the growth of …

Autophagy, a recycling process in eukaryotes, contributes to tumor growth and metastasis by
alleviating cellular stress and facilitating survival and chemoresistance. The development of …

Multi-modal combination therapy is regarded as a promising approach to cancer treatment.
Combining chemotherapy and phototherapy is an essential multi-modal combination …

Pancreatic ductal adenocarcinoma (PDAC) has a minimal (< 15%) 5-year existence, in part
due to resistance to chemoradiotherapy. Previous research reveals the impact of paricalcitol …

The folding of the guanine repetitive region in the telomere unit into G-quadruplex (G4) by
drugs has been suggested as an alternative approach for cancer therapy …

Drug repurposing and rescuing have been widely explored as cost-effective approaches to
expand the portfolio of chemotherapeutic agents. Based on the reported antitumor …