Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as
an endocrine hormone that signals to distinct targets throughout the body. Interest in …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Lifestyle modifications focused on healthy eating and regular exercise are the primary
recommendations for patients with nonalcoholic steatohepatitis (NASH). However, for …

It has been more than a dozen years since FGF21 burst on the metabolism field in a paper
showing that its pharmacologic administration caused weight loss and improved insulin …

Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some
adult humans, residuals of brown adipose tissue are adjacent to the central nervous system …

The worldwide epidemics of obesity, hypertriglyceridemia, dyslipidaemia, type 2 diabetes,
and metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction …

Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the
detrimental effects of inebriation. In this report, we show that the hormone FGF21, which is …

Experimental fibroblast growth factor 21 (FGF21) analogs can improve lipid profiles in
patients with metabolic diseases. However, their effects on markers of insulin sensitivity …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …