Fluid biomarkers in multiple sclerosis: from current to future applications

M Di Filippo, L Gaetani, D Centonze… - The Lancet Regional …, 2024 - thelancet.com
Multiple sclerosis (MS) is an immune-mediated inflammatory and degenerative disorder of
the central nervous system (CNS) with heterogeneous clinical manifestations. In the last …

Network analysis in multiple sclerosis and related disorders

G Pontillo, MB Cepas, TAA Broeders… - Neuroimaging …, 2024 - neuroimaging.theclinics.com
Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease of the central
nervous system that is increasingly conceptualized as a network disorder. 1, 2 While the …

Validity of serum neurofilament light chain as a prognostic biomarker of disease activity in multiple sclerosis

MK Sen, MJ Hossain, DA Mahns, BJ Brew - Journal of Neurology, 2023 - Springer
Multiple sclerosis (MS) is a chronic demyelinating and neuroinflammatory disease of the
human central nervous system with complex pathoetiology, heterogeneous presentations …

An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression

P Ananthavarathan, N Sahi… - Expert Review of …, 2024 - Taylor & Francis
Introduction While magnetic resonance imaging (MRI) is established in diagnosing and
monitoring disease activity in multiple sclerosis (MS), its utility in predicting and monitoring …

A review on multiple sclerosis prognostic findings from imaging, inflammation, and mental health studies

J Brasanac, C Chien - Frontiers in Human Neuroscience, 2023 - frontiersin.org
Magnetic resonance imaging (MRI) of the brain is commonly used to detect where chronic
and active lesions are in multiple sclerosis (MS). MRI is also extensively used as a tool to …

Neuroimaging to monitor worsening of multiple sclerosis: advances supported by the grant for multiple sclerosis innovation

J Oh, L Airas, D Harrison, E Järvinen… - Frontiers in …, 2023 - frontiersin.org
Key unmet needs in multiple sclerosis (MS) include detection of early pathology, disability
worsening independent of relapses, and accurate monitoring of treatment response …

Mapping structural disconnection and morphometric similarity alterations in multiple sclerosis

M Tranfa, M Petracca, M Moccia, A Scaravilli, F Barkhof… - medRxiv, 2024 - medrxiv.org
Whilst multiple sclerosis (MS) can be conceptualized as a network disorder, brain network
analyses are typically dependent on advanced MRI sequences not commonly acquired in …

Tract-wise microstructural analysis informs on current and future disability in early multiple sclerosis

V Ravano, GF Piredda, J Krasensky, M Andelova… - Journal of …, 2024 - Springer
Objectives Microstructural characterization of patients with multiple sclerosis (MS) has been
shown to correlate better with disability compared to conventional radiological biomarkers …

Conventional MRI-Based Structural Disconnection and Morphometric Similarity Networks and Their Clinical Correlates in Multiple Sclerosis

M Tranfa, M Petracca, M Moccia, A Scaravilli, F Barkhof… - Neurology, 2025 - neurology.org
Background and Objectives Although multiple sclerosis (MS) can be conceptualized as a
network disorder, brain network analyses typically require advanced MRI sequences not …

Predicting disease severity in multiple sclerosis using multimodal data and machine learning

M Andorra, A Freire, I Zubizarreta, NK de Rosbo… - Journal of …, 2024 - Springer
Background Multiple sclerosis patients would benefit from machine learning algorithms that
integrates clinical, imaging and multimodal biomarkers to define the risk of disease activity …