Advances in the chemistry of tetrahydroquinolines
V Sridharan, PA Suryavanshi, JC Menendez - Chemical reviews, 2011 - ACS Publications
1.1. General Heterocyclic compounds, especially nitrogen heterocycles, are the most
important class of compounds in the pharmaceutical and agrochemical industries, with …
important class of compounds in the pharmaceutical and agrochemical industries, with …
Recent progress in the development of new antimalarial drugs with novel targets
TM Belete - Drug design, development and therapy, 2020 - Taylor & Francis
Malaria is a major global health problem that causes significant mortality and morbidity
annually. The therapeutic options are scarce and massively challenged by the emergence of …
annually. The therapeutic options are scarce and massively challenged by the emergence of …
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Chemogenetic characterization through in vitro evolution combined with whole-genome
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …
MalDA, accelerating malaria drug discovery
The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories.
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …
Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Although many new anti-infectives have been discovered and developed solely using
phenotypic cellular screening and assay optimization, most researchers recognize that …
phenotypic cellular screening and assay optimization, most researchers recognize that …
Prioritization of molecular targets for antimalarial drug discovery
B Forte, S Ottilie, A Plater, B Campo… - ACS infectious …, 2021 - ACS Publications
There is a shift in antimalarial drug discovery from phenotypic screening toward target-
based approaches, as more potential drug targets are being validated in Plasmodium …
based approaches, as more potential drug targets are being validated in Plasmodium …
Plasmodium falciparum apicoplast drugs: targets or off-targets?
The phylum Apicomplexa includes obligate intracellular parasites that cause both benign
and serious diseases. Human infection by Toxoplasma gondii can be asymptomatic but can …
and serious diseases. Human infection by Toxoplasma gondii can be asymptomatic but can …
Advances in the reduction of quinolines to 1, 2, 3, 4‐tetrahydroquinolines
M El‐Shahat - Journal of Heterocyclic Chemistry, 2022 - Wiley Online Library
The pursuit of modern sustainable chemistry has stimulated the development of innovative
catalytic processes that enable chemical transformations to be performed under mild and …
catalytic processes that enable chemical transformations to be performed under mild and …
Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications
Malaria drug resistance contributes to up to a million annual deaths. Judicious deployment
of new antimalarials and vaccines could benefit from an understanding of early molecular …
of new antimalarials and vaccines could benefit from an understanding of early molecular …
The prenylated proteome of Plasmodium falciparum reveals pathogen-specific prenylation activity and drug mechanism-of-action
Plasmodium parasites contain several unique membrane compartments in which prenylated
proteins may play important roles in pathogenesis. Protein prenylation has also been …
proteins may play important roles in pathogenesis. Protein prenylation has also been …