Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

Thioredoxin and thioredoxin reductase are evolutionarily conserved antioxidant enzymes
that protect organisms from oxidative stress. These proteins also play roles in redox …

Targeting overexpressed thioredoxin reductase (TrxR) in cancer cells to induce oxidative
stress has been proved to be an effective strategy for cancer therapy. However, the …

Thioredoxin (Trx) is a compact redox-regulatory protein that modulates cellular redox state
by reducing oxidized proteins. Trx exhibits dual functionality as an antioxidant and a cofactor …

Thioredoxin, glutaredoxin and peroxiredoxin systems play central roles in redox regulation,
signaling and metabolism in cells. In these systems, reducing equivalents from NAD (P) H …

Selenium (Se) is an essential trace element of the utmost importance to human health. Its
deficiency induces various disorders. Se species can be absorbed by organisms and …

Alzheimer's disease (AD) is the most common form of dementia and a public health problem.
It exhibits significant oxidative stress and redox alterations. The antioxidant enzyme systems …

This review systematizes information about the metabolic features of breast cancer directly
related to oxidative stress. It has been shown those redox changes occur at all levels and …

Metabolism is controlled to ensure organismal development and homeostasis. Several
mechanisms regulate metabolism, including allosteric control and transcriptional regulation …

Obstructive sleep apnea hypopnea syndrome (OSAHS), typically characterized by chronic
intermittent hypoxia (CIH), is associated with renal injury in children. The activation of …