Covering: 2016 up to 2021 Mass spectrometry (MS) is an essential technology in natural
products research with MS fragmentation (MS/MS) approaches becoming a key tool. Recent …

Bioassay-guided fractionation in association with LC-MS and NMR detection led to the
isolation of six new alkaloids, sclerotiamides C–H (1–6), from the marine gorgonian-derived …

The potent and selective Gq protein inhibitor depsipeptide FR900359 (FR), originally
discovered as the product of an uncultivable plant endosymbiont, is synthesized by a …

Chemoinformatic and bioassay-guided fractionation of a gorgonian coral Junceella juncea
resulted in the isolation of 45 briarane-type diterpenoids, of which 16 new analogues were …

Simple Summary Uveal melanoma is a deadly form of eye cancer with a high rate of
metastasis. Once metastasis occurs, patients are often left with a short survival time, since …

Transmembrane signals initiated by a range of extracellular stimuli converge on members of
the Gq family of heterotrimeric G proteins, which relay these signals in target cells. Gq family …

Heterotrimeric G proteins are molecular switches in GPCR signaling pathways and regulate
a plethora of physiological and pathological processes. GPCRs are efficient drug targets …

G proteins are key mediators of G protein‐coupled receptor (GPCR) signaling, facilitating a
plethora of important physiological processes. The role of G proteins is much less …

Covering: up to April 2021 The bacterial cyclic depsipeptides FR900359 (FR) and YM-
254890 (YM) were shown to selectively inhibit Gαq proteins with high potency and selectivity …

The NBOMe family is a group of new psychoactive substances (NPSs). In this study, the
fragmentation patterns of NBOMe derivatives were analyzed using liquid chromatography …