The microenvironment (local environment), including viscosity, temperature, polarity,
hypoxia, and acidic-basic status (pH), plays indispensable roles in cellular processes …

Bioluminescence is the fascinating natural phenomenon by which living creatures produce
light. Bioluminescence occurs when the oxidation of a small-molecule luciferin is catalysed …

in vivo bioluminescence imaging (BLi) is an optical molecular imaging technique used to
visualize molecular and cellular processes in health and diseases and to follow the fate of …

Although fluorescent reporters and biosensors have become indispensable tools in
biological and biomedical fields, fluorescence measurements require external excitation …

Activity-based sensing (ABS) probes equipped with a NIR bioluminescence readout are
promising chemical tools to study cancer biomarkers owing to their high sensitivity and deep …

Biocatalysts are the backbone of bioprocessing industries that are going through a phase of
transition with reference to the requirement of extraordinary enzymes for various …

This review examines the vast catalytic and therapeutic potential offered by type I (ie oxygen-
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …

As one of the most representative hypoxic enzymes, nitroreductases (NTRs) play
momentous roles in malignant tumor progression, metastasis, invasion and angiogenesis …

Iron is an essential metal for all organisms, yet disruption of its homeostasis, particularly in
labile forms that can contribute to oxidative stress, is connected to diseases ranging from …

Tissue oxygenation is a driving parameter of the tumor microenvironment, and hypoxia can
be a prognostic indicator of aggressiveness, metastasis, and poor response to therapy …