Genome function, replication, integrity, and propagation rely on the dynamic structural organization of chromosomes during the cell cycle. Genome folding in interphase provides …
Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is still emerging. Here, we show a prominent role for cohesin in the expression of genes that …
O Symmons, VV Uslu, T Tsujimura, S Ruf… - Genome …, 2014 - genome.cshlp.org
Long-range regulatory interactions play an important role in shaping gene-expression programs. However, the genomic features that organize these activities are still poorly …
MJ Thiecke, G Wutz, M Muhar, W Tang, S Bevan… - Cell reports, 2020 - cell.com
It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state …
Current epigenomics approaches have facilitated the genome-wide identification of regulatory elements based on chromatin features and transcriptional regulator binding and …
C Balbás-Martínez, A Sagrera… - Nature …, 2013 - nature.com
Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological and genetic levels. Tumor invasiveness (T) and grade (G) are the main factors associated with outcome …
A Losada - Nature Reviews Cancer, 2014 - nature.com
Cohesin is an evolutionarily conserved, four-subunit complex that entraps DNA fibres within its ring-shaped structure. It was originally identified and named for its role in mediating sister …
Y Guo, K Monahan, H Wu, J Gertz… - Proceedings of the …, 2012 - National Acad Sciences
The closely linked human protocadherin (Pcdh) α, β, and γ gene clusters encode 53 distinct protein isoforms, which are expressed in a combinatorial manner to generate enormous …
G Wutz, R Ladurner, BG St Hilaire, RR Stocsits… - Elife, 2020 - elifesciences.org
Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is …