Phaeochromocytoma and paraganglioma (PPGL) are chromaffin cell tumours that require
timely diagnosis because of their potentially serious cardiovascular and sometimes life …

Tumors driven by deficiency of the VHL gene product, which is involved in degradation of
the hypoxia-inducible factor subunit 2 alpha (HIF2α), are natural candidates for targeted …

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that
arise from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic …

The mechanisms triggering metastasis in pheochromocytoma/paraganglioma are unknown,
hindering therapeutic options for patients with metastatic tumors (mPPGL). Herein we show …

The genetics of pheochromocytoma and paraganglioma (PPGL) has become increasingly
complex over the last two decades. The list of genes involved in the development of these …

Mutations that drive the stabilization of hypoxia inducible factor 2α (HIF2α) and downstream
pseudohypoxic signaling are known to predispose to the development of …

Abstract Context Pheochromocytomas and paragangliomas (PPGLs) are characterized by
distinct genotype-phenotype relationships according to studies largely restricted to …

Pheochromocytomas and paragangliomas (PPGLs) are adrenal or extra-adrenal
autonomous nervous system-derived tumors. Most PPGLs are benign, but approximately …

Germline or somatic driver mutations linked to specific phenotypic features are identified in
approximately 70% of all catecholamine-producing pheochromocytomas and …

Abstract Pheochromocytomas (PCCs) and paragangliomas (PGLs, together PPGLs) are the
most hereditary tumors known. PPGLs were considered benign, but the fourth edition of the …