Progress on mechanisms of age-related hearing loss

W Yang, X Zhao, R Chai, J Fan - Frontiers in neuroscience, 2023 - frontiersin.org
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly
people worldwide. It typically presents as progressive, irreversible, and usually affects the …

[HTML][HTML] Age-related hearing loss: the link between inflammaging, immunosenescence, and gut dysbiosis

D Kociszewska, S Vlajkovic - International Journal of Molecular Sciences, 2022 - mdpi.com
This article provides a theoretical overview of the association between age-related hearing
loss (ARHL), immune system ageing (immunosenescence), and chronic inflammation …

The stria vascularis in mice and humans is an early site of age-related cochlear degeneration, macrophage dysfunction, and inflammation

H Lang, KV Noble, JL Barth, JA Rumschlag… - Journal of …, 2023 - Soc Neuroscience
Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting
communication and quality of life for millions of older adults. Multiple pathophysiologic …

Blood–Labyrinth Barrier in Health and Diseases: Effect of Hormetic Nutrients

A Cosentino, A Agafonova, S Modafferi… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The stria vascularis, located in the inner ear, consists of three layers, one of
which is the blood–labyrinth barrier (BLB). It is formed by endothelial cells, sealed together …

Cochlear inflammaging: cellular and molecular players of the innate and adaptive immune system in age-related hearing loss

S Parekh, T Kaur - Frontiers in Neurology, 2023 - frontiersin.org
Age-related hearing loss is the most common sensory disorder worldwide that contributes to
numerous health conditions in the aging population. Despite its prevalence, current …

[HTML][HTML] Piceatannol protects against age-related hearing loss by inhibiting cellular pyroptosis and inflammation through regulated Caspase11-GSDMD pathway

X Yang, Y Wu, M Zhang, L Zhang, T Zhao… - Biomedicine & …, 2023 - Elsevier
Age-related hearing loss (ARHL) is a common issue associated with aging. One of the
typical causes of hearing loss is the damage to inner ear hair cells. In addition, oxidative …

Understanding the role of inflammation in sensorineural hearing loss: current goals and future prospects

L Li, D Chen, X Lin, J Luo, J Tan, P Li - Brain‐X, 2023 - Wiley Online Library
Sensorineural hearing loss (SNHL) is a common otologic condition caused by damage to
hair cells and spiral ganglion neurons that affects transmission pathways. Most of these cells …

Natural products: protective effects against sensorineural hearing loss

W Xu, M Huang, M Liao, S Mao, L Yang… - Phytochemistry Reviews, 2024 - Springer
Hearing loss is one of the major public health problems in the world, which brings huge
adverse effects to individuals and society. Sensorineural hearing loss (SNHL) is responsible …

Post-translational modifications and age-related hearing loss

P Bazard, J Pineros, AA Acosta, M Thivierge… - Hearing Research, 2022 - Elsevier
Post-translational modifications (PTMs) affect nearly all systems of the human body due to
their role in protein synthesis and functionality. These reversible and irreversible …

L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice

MA Bauer, P Bazard, AA Acosta, N Bangalore… - Hearing Research, 2024 - Elsevier
The naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a
therapeutic, having shown promise in the treatment of other disease models, including …