Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

[HTML][HTML] Type II diabetes mellitus: a review on recent drug based therapeutics

S Padhi, AK Nayak, A Behera - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder that occurs in the body because of decreased
insulin activity and/or insulin secretion. Pathological changes such as nephropathy …

Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: Applications, advantages and disadvantages

P Ghasemiyeh… - Research in …, 2018 - journals.lww.com
During the recent years, more attentions have been focused on lipid base drug delivery
system to overcome some limitations of conventional formulations. Among these delivery …

[HTML][HTML] Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers

CH Lin, CH Chen, ZC Lin, JY Fang - Journal of food and drug analysis, 2017 - Elsevier
Chemical and enzymatic barriers in the gastrointestinal (GI) tract hamper the oral delivery of
many labile drugs. The GI epithelium also contributes to poor permeability for numerous …

Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Solid lipid nanoparticles for enhanced oral absorption: A review

E Salah, MM Abouelfetouh, Y Pan, D Chen… - colloids and surfaces B …, 2020 - Elsevier
Recent trends in nanoparticles-based oral therapy have led to a proliferation of studies to
enhance solubility, permeability and chemical stability of many drugs. One of the significant …

Tailoring the multi-functional properties of phospholipids for simple to complex self-assemblies

T Waghule, RN Saha, A Alexander, G Singhvi - Journal of Controlled …, 2022 - Elsevier
The unique interfacial properties, huge diversity, and biocompatible nature of phospholipids
make them an attractive pharmaceutical excipient. The amphiphilic nature of these …

A recent update: solid lipid nanoparticles for effective drug delivery

S Pandey, F Shaikh, A Gupta… - Advanced …, 2021 - pmc.ncbi.nlm.nih.gov
Solid lipid nanoparticles (SLNs) are one of the developed technologies for addressing the
bioavailability and targeting issues of drug delivery. In this review article, we attempted to …

Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in …

M Cirri, L Maestrini, F Maestrelli, N Mennini, P Mura… - Drug …, 2018 - Taylor & Francis
The hydrochlorothiazide (HCT) low solubility and permeability give rise to limited and
variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid …

Advantages of the combined use of cyclodextrins and nanocarriers in drug delivery: A review

P Mura - International journal of pharmaceutics, 2020 - Elsevier
Complexation with cyclodextrins (CDs) has been widely and successfully used in
pharmaceutical field, mainly for enhancing solubility, stability and bioavailability of a variety …