Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

Drugs that contain phosphates (and phosphonates or phosphinates) have intrinsic
absorption issues and are therefore often delivered in prodrug forms to promote their uptake …

Abstract γδ T cells are potent anticancer effectors with the potential to target tumours
broadly, independent of patient-specific neoantigens or human leukocyte antigen …

Seminal yeast studies have established the value of comprehensively mapping genetic
interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets …

Solute carriers (SLCs) are the largest family of transmembrane transporters in humans and
are major determinants of cellular metabolism. Several SLCs have been shown to be …

Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease the
surface tension and facilitate inspiration. Surfactant deficiency is often seen in premature …

Abstract Vγ9Vδ2 T cells are specialized effector cells that have gained prominence as
immunotherapy agents due to their ability to target and kill cells with altered pyrophosphate …

Lysosomes are degradative organelles in eukaryotic cells mediating the hydrolytic
catabolism of various macromolecules to small basic building blocks. These low‐molecular …

Classically, osteoclast fusion consists of four basic steps:(1) attraction/migration,(2)
recognition,(3) cell–cell adhesion, and (4) membrane fusion. In theory, this sounds like a …

Bisphosphonates (BPs), the stable analogs of pyrophosphate, are well-known inhibitors of
osteoclastogenesis to prevent osteoporotic bone loss and improve implant osseointegration …