Membranes are essential for cells and organelles to function. As membranes are
impermeable to most polar and charged molecules, they provide electrochemical energy to …

Protein kinase C (PKC) modulators are currently of great importance in preclinical and
clinical studies directed at cancer, immunotherapy, HIV eradication, and Alzheimer's …

The development of the male gametophyte is a tightly regulated process that requires the
precise control of cell division and gene expression. A relevant aspect to understand the …

Abstract Background The European spurge hawkmoth, Hyles euphorbiae (Lepidoptera,
Sphingidae), has been intensively studied as a model organism for insect chemical ecology …

Munc13-1 is a presynaptic active zone protein that acts as a master regulator of synaptic
vesicle priming and neurotransmitter release in the brain. It has been implicated in the …

C1 domains are lipid-binding structural units of about 50 residues. Typical C1 domains
associate with the plasma membrane and bind to diacylglycerol/phorbol ester during the …

Human serum albumin (HSA) is the major transport protein affording endogenous and
exogenous substances in plasma. It can affect the behavior and efficacy of chemicals in vivo …

Curcumin is a polyphenolic nutraceutical that acts on multiple biological targets, including
protein kinase C (PKC). PKC is a family of serine/threonine kinases central to intracellular …

Munc13-1 is a presynaptic active zone protein that plays a critical role in priming the
synaptic vesicle and releasing neurotransmitters in the brain. Munc13-1 acts as a scaffold …

Increasing protein kinase C (PKC) activity is of potential therapeutic value. Its activation
involves an interaction between the C1 domain and diacylglycerol (DAG) at intracellular …