Mesenchymal stem cell–derived exosomes: a promising biological tool in nanomedicine

W Wei, Q Ao, X Wang, Y Cao, Y Liu… - Frontiers in …, 2021 - frontiersin.org
As nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes, in particular,
exosomes derived from mesenchymal stem cells (MSC-exosomes), have been studied in …

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy

S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …

Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src

X Xiao, M Xu, H Yu, L Wang, X Li, J Rak… - Signal transduction and …, 2021 - nature.com
Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium,
leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes …

MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system

T Wang, Z Jian, A Baskys, J Yang, J Li, H Guo, Y Hei… - Biomaterials, 2020 - Elsevier
Oxidative stress is a major cause of skin injury induced by damaging stimuli such as UV
radiation. Currently, owing to their immunomodulatory properties, mesenchymal stem cell …

[HTML][HTML] TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p …

Z Yu, Y Wen, N Jiang, Z Li, J Guan, Y Zhang, C Deng… - Biomaterials, 2022 - Elsevier
Retinal ischemia-reperfusion injury (IRI) is one of the main pathogenic mechanisms of
glaucoma, which are largely unknown, including neuroinflammation and neuronal death in …

Role of exosomes in central nervous system diseases

W Liu, X Bai, A Zhang, J Huang, S Xu… - Frontiers in molecular …, 2019 - frontiersin.org
There are many types of intercellular communication, and extracellular vesicles are one of
the important forms of this. They are released by a variety of cell types, are heterogeneous …

Exosomes engineering and their roles as therapy delivery tools, therapeutic targets, and biomarkers

N Kučuk, M Primožič, Ž Knez, M Leitgeb - International journal of …, 2021 - mdpi.com
Exosomes are becoming increasingly important therapeutic biomaterials for use in a variety
of therapeutic applications due to their unique characteristics, especially due to the …

Neural stem cell derived extracellular vesicles: attributes and prospects for treating neurodegenerative disorders

AD Vogel, R Upadhya, AK Shetty - EBioMedicine, 2018 - thelancet.com
Neural stem cell (NSC) grafting in conditions such as aging, brain injury, and
neurodegenerative diseases promotes regeneration, plasticity and functional recovery …

[HTML][HTML] Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway

W Ding, Q Gu, M Liu, J Zou, J Sun, J Zhu - International …, 2023 - Elsevier
Background Our previous studies have shown that berberine can improve the nerve function
deficits in ischemic stroke by inhibiting inflammation. The cellular communication between …

Native and bioengineered exosomes for ischemic stroke therapy

H Khan, JJ Pan, Y Li, Z Zhang, GY Yang - Frontiers in Cell and …, 2021 - frontiersin.org
Exosomes are natural cells-derived vesicles, which are at the forefront toward clinical
success for various diseases, including cerebral ischemia. Exosomes mediate cell-to-cell …