Cellular barcoding is a technique in which individual cells are labeled with unique nucleic
acid sequences, termed barcodes, so that they can be tracked through space and time …

The developmental basis for the localization of function in the mammalian cortex remains a
controversial issue. The newly formed rodent cortex displays a considerable uniformity in …

In Chance, Development, and Aging, two leading biological gerontologists review and
evaluate all of the available data to elucidate the respective roles played by genes and …

Neocortical neurons are produced by cell division of neural stem cells in the ventricular zone
of the cerebral cortex. We investigated the production of neurons by infecting neuroepithelial …

IN the adult cerebral cortex, many retrovirally labelled clones are widely dispersed1, though
the mechanisms of this dispersion are not well understood. Here we investigate the temporal …

We have labelled precursor cells in the embryonic rat cerebral cortex using BAG, a retroviral
vector that expresses β-galactosidase. We had previously reported that labelled precursor …

Replication-incompetent retroviral vectors encoding histochemical reporter genes have
been used for studying lineal relationships in a variety of species. A crucial element in the …

The morphological, molecular, and functional heterogeneity of astrocytes is under intense
scrutiny, but how this diversity is ontogenetically achieved remains largely unknown. Here …

Inactivation of the X-linked lacZ transgene provides a novel and powerful way of
distinguishing between clonally related cellular populations in X inactivation mosaics. This …

Highlights•Cell lineage underlies the developmental steps taken to acquire cell
identity.•Genetic labeling allows lineage tracing with cell type and temporal …