The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Arterial stiffness progressively increases with aging and is an independent predictor of
cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the …

The combination of obesity and hypertension is associated with high morbidity and mortality
because it leads to cardiovascular and kidney disease. Potential mechanisms linking …

The goal of this review is to provide further understanding of increased vascular stiffness
with aging, and how it contributes to the adverse effects of major human diseases …

Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Arterial remodeling refers to the structural and functional changes of the vessel wall that
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …

Arterial aging engages a plethora of key signalling pathways that act in concert to induce
vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration …

Climie et al Macrovasculature and Microvasculature in HTN and T2D 1139 million global
disability-adjusted life years, an increase of 11.7% from 2005. 9 Because hypertension …

Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …

Vascular stiffness is a mechanical property of the vessel wall that affects blood pressure,
permeability, and inflammation. As a result, vascular stiffness is a key driver of (chronic) …