Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Among all the stromal cells that present in the tumor microenvironment, cancer-associated
fibroblasts (CAFs) are one of the most abundant and critical components of the tumor …

Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the
malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistance …

Cancer-associated fibroblasts (CAFs) are one of the most significant components in the
tumour microenvironment (TME), where they can perform several protumourigenic functions …

Increasing lines of evidence show that the malignant behavior of cancer is not exclusively
attributable to cancer cells but also radically influenced by cancerous stroma activity and …

Fibroblasts regulate the structure and function of healthy tissues, participate transiently in
tissue repair after acute inflammation, and assume an aberrant stimulatory role during …

There is much cellular heterogeneity in the tumor microenvironment. The tumor epithelia
and stromal cells co-evolve, and this reciprocal relationship dictates almost every step of …

Stroma in the tumor microenvironment plays a critical role in cancer progression, but how it
promotes metastasis is poorly understood. Exosomes are small vesicles secreted by many …

Fibroblast activation protein (FAP) is a membrane protease that is highly expressed by
cancer-associated fibroblasts (CAFs). FAP can modulate the tumor microenvironment (TME) …

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …