Cerebral plasticity: Windows of opportunity in the developing brain
Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in …
nervous system (CNS) to undergo maturation, change structurally and functionally in …
[HTML][HTML] The anatomical basis for dystonia: the motor network model
Background The dystonias include a clinically and etiologically very diverse group of
disorders. There are both degenerative and non-degenerative subtypes resulting from …
disorders. There are both degenerative and non-degenerative subtypes resulting from …
Dystonia as a network disorder: what is the role of the cerebellum?
CN Prudente, EJ Hess, HA Jinnah - Neuroscience, 2014 - Elsevier
The dystonias are a group of disorders defined by sustained or intermittent muscle
contractions that result in involuntary posturing or repetitive movements. There are many …
contractions that result in involuntary posturing or repetitive movements. There are many …
The thalamostriatal system in normal and diseased states
Because of our limited knowledge of the functional role of the thalamostriatal system, this
massive network is often ignored in models of the pathophysiology of brain disorders of …
massive network is often ignored in models of the pathophysiology of brain disorders of …
Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
Addiction involves a predominance of habitual control mediated through action selection
processes in dorsal striatum. Research has largely focused on neural mechanisms …
processes in dorsal striatum. Research has largely focused on neural mechanisms …
Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions
KK Gonzales, Y Smith - Annals of the New York Academy of …, 2015 - Wiley Online Library
Striatal cholinergic interneurons (ChIs) are central for the processing and reinforcement of
reward‐related behaviors that are negatively affected in states of altered dopamine …
reward‐related behaviors that are negatively affected in states of altered dopamine …
Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration
Parkinson's disease is a progressive neurodegenerative disorder characterized by altered
striatal dopaminergic signalling that leads to motor and cognitive deficits. Parkinson's …
striatal dopaminergic signalling that leads to motor and cognitive deficits. Parkinson's …
[HTML][HTML] Dystonia and dopamine: from phenomenology to pathophysiology
A line of evidence suggests that the pathophysiology of dystonia involves the striatum,
whose activity is modulated among other neurotransmitters, by the dopaminergic system …
whose activity is modulated among other neurotransmitters, by the dopaminergic system …
Convergence of cortical and thalamic input to direct and indirect pathway medium spiny neurons in the striatum
I Huerta-Ocampo, J Mena-Segovia… - Brain Structure and …, 2014 - Springer
The major afferent innervation of the basal ganglia is derived from the cortex and the
thalamus. These excitatory inputs mainly target the striatum where they innervate the …
thalamus. These excitatory inputs mainly target the striatum where they innervate the …
Hyperkinetic disorders and loss of synaptic downscaling
Recent clinical and preclinical studies have shown that hyperkinetic disorders such as
Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are …
Huntington's disease, dystonia and l-DOPA-induced dyskinesia in Parkinson's disease are …