Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

Retinitis Pigmentosa (RP) is a group of diseases in which one of a large number of
mutations causes death of rod photoreceptors. After rods die, cone photoreceptors slowly …

Diabetes mellitus is a world-wide epidemic and diabetic retinopathy, a devastating, vision-
threatening condition, is one of the most common diabetes-specific complications. Diabetic …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Purpose: AMD is the leading cause of irreversible blindness in older individuals in the
Western world, and there are currently no therapies to halt disease progression. Studies …

Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically
heterogeneous diseases characterized by the progressive degeneration of the retina …

Autophagosome-lysosome fusion is a common critical step in various forms of
macroautophagy/autophagy including mitophagy, the selective degradation of mitochondria …

Macroautophagy/autophagy is an essential process for cellular survival and is implicated in
many diseases. A critical step in autophagy is the transport of the transcription factor TFEB …

Retinitis pigmentosa (RP) is one of the most common clinical subtypes of retinal
degeneration (RD), and it is a neurodegenerative disease that could cause complete …

Retinal degenerative diseases are major causes of untreatable blindness worldwide and
efficacious treatments for these diseases are sorely needed. A novel target for treatment of …