Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Appropriate patterns of DNA methylation and histone modifications are required to assure
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …

Initially regarded as “epigenetic modifiers” acting predominantly through chromatin
remodeling via histone acetylation, HDACIs, alternatively referred to as lysine deacetylase …

The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and
EED, in which the SET (suppressor of variegation–enhancer of zeste-trithorax) domain of …

The orchestrated organization of epigenetic factors that control chromatin dynamism,
including DNA methylation, histone marks, non-coding RNAs (ncRNAs) and chromatin …

Vorinostat (Zolinza®), a histone deacetylase inhibitor, was approved by the US Food and
Drug Administration in October 2006 for the treatment of cutaneous manifestations in …

In eukaryotic cells, control mechanisms have developed that restrain cell-cycle transitions in
response to stress. These regulatory pathways are termed cell-cycle checkpoints. The G 2/M …

Vorinostat is a potent histone deacetylase inhibitor that blocks the catalytic site of these
enzymes. A large number of cellular proteins are modified post-translationally by acetylation …

Epigenetic drugs have been shown to enhance gene expression and drug sensitivity in
ovarian cancer cell lines and animal models. Based on promising preclinical studies, DNA …