Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …

Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Intraventricular haemorrhage (IVH) continues to be a major complication of prematurity that
can result in cerebral palsy and cognitive impairment in survivors. No optimal therapy exists …

Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …

Stroke is a major cause of death and disability worldwide. Yet therapeutic strategies
available to treat stroke are very limited. There is an urgent need to develop novel …

The discovery of the necroptosis, a form of regulated necrosis that is mediated by receptor-
interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like …

For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

Stroke is a major cause of death and adult disability. However, therapeutic options remain
limited. Numerous pathways underlie acute responses of brain tissue to stroke. Early events …